The Advanced
Material Characterisation (AMC) Facility is hosting a talk by Professor Bob
Price as part of the AMMS and AMAS Technical Meeting.
Title:
Some aspects of
imaging in colon cancer research
(Confocal and EM Research)
Speaker:
Professor Bob Price,
Research Professor, Developmental Biology
& Anatomy
Department Cell
Biology and Anatomy
School of Medicine
University of South
Carolina
When:
Monday 10th of February
2014
4.30pm-5.00pm Welcome drinks with Speaker
5.00pm-6.00pm Talk by Professor Bob Price
6.00pm to 6.30pm
Drinks with Speaker
Where:
University of Western Sydney
School of Science an Health
Parramatta North Campus
Building LZ.G.14
Cnr Pemberton Street and Victoria Road, Rydalmere NSW 2116
(Parking is available
on the campus for $6)
RSVP:
Some aspects of imaging in colon cancer research
(Confocal and EM Research)
Abstract: Investigators in the Center for
Colon Cancer Research at the University of South Carolina use the APCMin/+ mouse
model to address a number of questions concerning the development of tumors,
organization of tumor vasculature, and structural changes in peripheral muscle
as a result of weight loss (cachexia) associated with tumor development. In
this presentation I will briefly address aspects of the confocal and electron
microscopy studies we have performed to study this important model of colon
cancer. The APCMin/+ mouse is a genetic model of
gastrointestinal tumorigenesis that involves the adenomatous polyposis coli (APC)
gene. Mice that are heterozygous for this allele spontaneously develop multiple
adenomatous polyps throughout the gastrointestinal tract. This phenotype is
similar to that found in humans with familial adenomatous polyposis, an
inherited form of colon cancer. The same gene is mutated in a majority of
sporadic human colorectal cancers [1]. Various forms of imaging are important
in study of the model and ongoing microscopy projects examining the
distribution of bone marrow derived cell (BMDC) infiltration of
intestinal tumors, vascular casting and in vivo confocal imaging of tumor vasculature,
and ultrastructural changes that occur in skeletal muscle associated with
cachexia in the model will be described.
Biography: Professor Bob Price is the
Research Professor for the Developmental Biology & Anatomy within the
Department Cell Biology and Anatomy, School of Medicine, University of South
Carolina. Bob is also the Editor, Biological Applications, Microscopy and
Microanalysis and the Editor-in-Chief, Microscopy and Microanalysis, The
Journal of the Microscopy Society of America.
Dr. Price has
managed core biotechnology facilities for more than 27 years and has extensive
training and research experience in a variety of microscopy technologies
including light, confocal scanning laser, and scanning and transmission
electron microscopy. He has received a number of research and equipment grants
from the National Institutes of Health and the American Heart Association
related to heart development, colon cancer, and various imaging technologies.
He has also reviewed grants for NIH, the National Science Foundation, AHA and
other granting agencies that involve imaging technology. He is currently the
Editor-in-Chief of Microscopy and Microanalysis, the journal of the Microscopy
Society of America and the Official Journal of AMMS, has recently co-authored a
book on confocal microscopy “Basic Confocal Microscopy” published through
Springer, and in 2012 was elected as a Fellow of the Microscopy Society of
America.
