AMMS and AMAS Technical Meeting

The Advanced Material Characterisation (AMC) Facility is hosting a talk by Professor Bob Price as part of the AMMS and AMAS Technical Meeting.

Title:           

Some aspects of imaging in colon cancer research 
(Confocal and EM Research)

Speaker:      

Professor Bob Price,

Research Professor, Developmental Biology & Anatomy

Department Cell Biology and Anatomy 
School of Medicine 
University of South Carolina

When:        

Monday 10^th of February 2014

4.30pm-5.00pm Welcome drinks with Speaker

5.00pm-6.00pm Talk by Professor Bob Price
6.00pm to 6.30pm Drinks with Speaker

Where:    
University of Western Sydney
School of Science an Health
Parramatta North Campus
Building LZ.G.14
Cnr Pemberton Street and Victoria Road, Rydalmere NSW 2116
(Parking is available on the campus for $6)

RSVP: 

Friday 7^th of February 2014 to Richard Wuhrer (Richard.Wuhrer@uws.edu.au)

Some aspects of imaging in colon cancer research (Confocal and EM Research)

Abstract: Investigators in the Center for Colon Cancer Research at the University of South Carolina use the APC^Min/+ mouse model to address a number of questions concerning the development of tumors, organization of tumor vasculature, and structural changes in peripheral muscle as a result of weight loss (cachexia) associated with tumor development. In this presentation I will briefly address aspects of the confocal and electron microscopy studies we have performed to study this important model of colon cancer. The APC^Min/+ mouse is a genetic model of gastrointestinal tumorigenesis that involves the adenomatous polyposis coli (APC) gene. Mice that are heterozygous for this allele spontaneously develop multiple adenomatous polyps throughout the gastrointestinal tract. This phenotype is similar to that found in humans with familial adenomatous polyposis, an inherited form of colon cancer. The same gene is mutated in a majority of sporadic human colorectal cancers [1]. Various forms of imaging are important in study of the model and ongoing microscopy projects examining the distribution of bone marrow derived cell (BMDC)  infiltration of intestinal tumors, vascular casting and in vivo confocal imaging of tumor vasculature, and ultrastructural changes that occur in skeletal muscle associated with cachexia in the model will be described.

Biography: Professor Bob Price is the Research Professor for the Developmental Biology & Anatomy within the Department Cell Biology and Anatomy, School of Medicine, University of South Carolina. Bob is also the Editor, Biological Applications, Microscopy and Microanalysis and the Editor-in-Chief, Microscopy and Microanalysis, The Journal of the Microscopy Society of America.

Dr. Price has managed core biotechnology facilities for more than 27 years and has extensive training and research experience in a variety of microscopy technologies including light, confocal scanning laser, and scanning and transmission electron microscopy. He has received a number of research and equipment grants from the National Institutes of Health and the American Heart Association related to heart development, colon cancer, and various imaging technologies. He has also reviewed grants for NIH, the National Science Foundation, AHA and other granting agencies that involve imaging technology. He is currently the Editor-in-Chief of Microscopy and Microanalysis, the journal of the Microscopy Society of America and the Official Journal of AMMS, has recently co-authored a book on confocal microscopy “Basic Confocal Microscopy” published through Springer, and in 2012 was elected as a Fellow of the Microscopy Society of America.

For further information regarding the AMC Facility Please visit our website http://www.uws.edu.au/innovation/home/instrumentation